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Melanoma under Dermoscopy

Under dermoscopy, malignant melanoma can often be characterized by atypical pigment networks, irregular dot-ball shapes, and a bluish-white veil. For a clear view, the physician needs to clean the patient’s skin area under observation in advance and adjust the dermoscopic focus until the lesion is magnified to the appropriate size. Through dermoscopy, doctors can detect…


Mastering Dermoscopy: Melanoma, In Situ Features & Images Guide | IBOOLO

Master dermoscopy melanoma. Learn to identify key dermoscopic features of melanoma and subtle signs of melanoma in situ with our expert guide. Explore IBOOLO diagnostic tools to enhance your practice.

Mastering Dermoscopy features for Melanoma in situ: A Comprehensive Guide to Early Detection

In the field of dermatology, no tool has had a greater impact on the early detection of skin cancer than the dermatoscope. For clinicians, mastering dermoscopy melanoma is a critical skill, offering a non-invasive window into the subtle, microscopic world of skin lesions. The stakes are high: diagnosing melanoma at its earliest stage, particularly as melanoma in situ, can lead to a nearly 100% cure rate. Conversely, a missed or delayed diagnosis can be life-threatening. This guide provides a definitive, expert-level overview of the dermoscopic features of melanoma, empowering professionals and advanced enthusiasts to interpret melanoma under dermoscopy with unparalleled confidence. By combining theoretical knowledge with practical application, we will unveil the secrets that dermoscopy holds, from classic signs to the most subtle clues of malignancy.

The Classic Dermoscopic Features of Melanoma: The ABCDs and Beyond

While the clinical ABCDEs (Asymmetry, Border, Color, Diameter, Evolving) offer a foundational framework, dermoscopy provides a much more granular view. When analyzing dermoscopy images of melanoma, dermatologists look for a specific set of features that reveal the lesion's true nature. Mastery of these patterns is essential for accurate diagnosis.

Asymmetry in Shape and Structure

Unlike benign moles, which are often symmetrical and uniform, melanoma typically displays asymmetry in multiple dimensions. Under dermoscopy, this manifests as:

  • Asymmetry of Shape: The lesion is divided into two halves that do not mirror each other.
  • Asymmetry of Structure: Different areas of the lesion contain distinct patterns. For example, one quadrant may show a pigment network, while another shows dots and streaks. This structural chaos is a hallmark of melanoma.

Irregular Borders and Margins

The edges of a benign lesion are usually sharp and well-defined. In contrast, melanoma's borders are often irregular, blurred, or ill-defined. This irregularity reflects the uncontrolled, chaotic growth of malignant cells. On dermoscopy, look for:

  • Irregular Outlines: Jagged, notched, or lobular borders instead of a smooth, circular shape.
  • Pseudopods and Streaks: Finger-like projections or linear streaks extending irregularly from the lesion's edge. These are highly suspicious findings that indicate radial growth.

Color Diversity and Irregular Distribution

Benign moles tend to have a single, uniform color. Melanoma, however, often exhibits a striking variety of colors, a phenomenon known as variegation. The distribution of these colors is also irregular and haphazard. Common colors seen under dermoscopy include:

  • Black: Often seen as black dots, globules, or a solid black patch.
  • Brown: The most common color, appearing in different shades.
  • Blue/Gray: A "blue-white veil" or "blue-gray globules" are particularly concerning and suggest the presence of pigment in the deeper dermis.
  • Red/Pink: Can indicate inflammation or the presence of blood vessels.
  • White: Often a sign of regression, indicating the body's immune response has destroyed some of the melanoma cells.

The Significance of Special Structures

Beyond color and borders, melanoma is characterized by several specific structural patterns visible with dermoscopy. These clues are often what distinguish melanoma from other lesions.

  • Atypical Pigment Network: Unlike the uniform, regular network of a benign mole, melanoma's network is often thick, broken, or has irregular meshes. This is a crucial feature for diagnosing melanoma in situ dermoscopy.
  • Irregular Dots and Globules: Benign lesions may have small, uniform dots or globules. Melanoma, however, often presents with dots and globules of varying sizes, shapes, and colors, distributed irregularly throughout the lesion.
  • Atypical Vascular Patterns: The presence of disorganized, comma-shaped, dotted, or linear-irregular blood vessels is a strong indicator of melanoma. These atypical vessels are a direct result of the tumor's need for a new blood supply to fuel its growth.

The Clinician's Toolkit: From Theory to Practice

Mastering the interpretation of dermoscopic features of melanoma is a journey that requires not only knowledge but also the right tools and a systematic approach. The transition from theory to practice is where a clinician's skill truly shines.

A Systematic Diagnostic Workflow

A reliable workflow ensures that no detail is overlooked. We recommend a systematic approach for every lesion:

  1. Clinical Observation: Begin with a standard visual inspection, noting the lesion's overall appearance and location.
  2. The Dermoscopic Examination: Using a high-quality dermatoscope, examine the lesion thoroughly. Start with low magnification to get a global view, then increase magnification to observe microscopic details.
  3. Pattern Recognition: Methodically apply the ABCDs and look for the special structures discussed above. Compare the lesion to the surrounding skin.
  4. Documentation and Follow-up: For any lesion with suspicious features, it is critical to capture high-resolution images for documentation and future comparison.

This systematic process is a cornerstone of modern dermatology and is essential for preventing missed diagnoses. For many high-risk patients, routine dermoscopic surveillance can be the key to early detection.

The Role of Technology: Enhancing Dermoscopic Diagnosis

While the human eye is a powerful tool, modern technology significantly enhances the diagnostic process. A high-quality dermatoscope, especially a hybrid one, is no longer just a magnifying glass; it's a critical component of a digital diagnostic system. Tools that allow for superior optics, versatile lighting modes, and seamless digital integration are invaluable.

For example, a device with a dedicated lens and powerful lighting, like the IBOOLO professional series, is designed to reveal the most subtle dermoscopic features of melanoma. By providing ultra-clear, high-magnification dermoscopy images of melanoma, it helps clinicians identify critical clues such as irregular pigment networks or atypical vessels that are often invisible with less advanced equipment. Furthermore, with the ability to capture, store, and share these images, a dermatoscope becomes a powerful tool for patient education, long-term monitoring, and second-opinion consultations.

Understanding melanoma under dermoscopy is a skill that directly translates to better patient outcomes. The ability to distinguish a benign mole from a malignant lesion with confidence saves lives and prevents unnecessary procedures. By mastering the core dermoscopic features of melanoma, from the classic ABCDs to subtle structural patterns, a clinician can significantly improve their diagnostic accuracy. With the aid of modern technology, a dermatoscope is transformed from a simple diagnostic tool into a powerful, data-rich system that stands at the forefront of the fight against skin cancer. The early detection of melanoma in situ is not just a clinical goal—it is a moral imperative, and dermoscopy is the key that unlocks it.


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Under dermoscopy, malignant melanoma can often be characterized by atypical pigment networks, irregular dot-ball shapes, and a bluish-white veil. For a clear view, the physician needs to clean the patient’s skin area under observation in advance and adjust the dermoscopic focus until the lesion is magnified to the appropriate size. Through dermoscopy, doctors can detect abnormalities in the early stages of melanoma, which can lead to timely intervention and treatment and reduce unnecessary harm.


Melanoma Basics
Melanoma is a type of skin cancer that develops in the skin cells called melanocytes. It can be found in the head and neck, trunk and extremities. Based on its histologic type, it is classified into the following main types: superficial diffuse melanoma, nodular melanoma, malignant freckle melanoma, and limb freckle melanoma.
Melanoma accounts for about 6.8% to 20% of cutaneous malignancies and is one of the more common tumors of the skin. It develops in adults, especially in middle-aged and elderly people. Fair-skinned Caucasians have a relatively high incidence, while dark-skinned Asians and Africans have a lower incidence. Exposure to ultraviolet light is an important predisposing factor for melanoma. Prolonged or intense UV exposure may damage melanocytes in the skin, thereby increasing the risk of melanoma.


Introduction to Dermoscopy
Dermoscopy is an instrument based on optical principles to observe the morphology and texture of the skin surface. Firstly, the skin of the area to be examined needs to be cleaned, and appropriate observation modes, such as amber light mode, polarized light mode, etc. Finally, the dermatoscope is placed on the skin of the area to be examined for observation.
Dermoscopy can clearly observe the morphology, color, boundary and other characteristics of the skin lesion, which helps doctors more accurately determine the nature and type of the lesion, thus improving the diagnostic accuracy of melanoma.

IBOOLO DE-300 Dermoscopy
IBOOLO DE-300 Dermoscopy


Preparation for Dermoscopy
Prior to dermoscopy, the patient should clean and dry the skin at the examination site, and the physician should choose between different types of dermoscopies (hand-held or digital) depending on the site and purpose of examination. Light in the test process should be uniform and moderate, not dazzling and shadows. They need to be aware of the principle of aseptic work and should be provided with sterile equipment and sterilized dermatoscope cleaned carefully before each patient in order to decrease the risk of infection.


How to Recognize Melanoma under Dermoscopy?
Melanomas demonstrate atypical pigment networks, irregular streaks, blue–white structures and irregular blood vessels in situ dermoscopy. The ABCDE rule is a guide to help you recognize melanoma.
A (Asymmetry) asymmetry: melanoma is usually asymmetric with irregular borders to the surrounding normal skin.
B (Border) Border: The border of a melanoma is usually unclear, showing jagged, irregular or fuzzy edges.
C (Color): Melanomas may be unevenly colored and present in a variety of colors.
D (Diameter): Melanomas are usually larger than 6 millimeters in diameter.
E (Evolution) Evolution: Melanomas can change over time, such as increasing in size, changing in color, developing itching, breaking down, etc.

Melanoma under Dermoscopy
Melanoma under Dermoscopy


Can dermatoscopy examine melanoma on all parts of the body?
Dermoscopy allows doctors to observe small changes in the surface of the skin and examine various parts of the body for skin pigmented diseases, such as malignant freckle-like nevus on the head and neck, superficial diffuse melanoma on the trunk area, nail melanoma and mucosal melanoma on the extremities. However, for deeper or complex melanomas, further skin biopsy may be required to identify them due to their complex structure.


Dermoscopy Images of Melanoma
Melanoma has a variety of specific patterns dermoscopically, including: atypical pigment networks, irregular streaks, irregular dots and balls, irregular stains, and blue-white curtains.
A patient, female, 59 years old, had a family history of malignant melanoma. An asymmetric, irregular brown patch, approximately 7 x 6 mm, was found on the right leg. dermoscopic images showed typical melanoma features-irregular streaks, irregular dots and balls, irregular stains, and blue-white curtains, among others. The final diagnosis was malignant melanoma

Dermoscopy Images of Melanoma
Dermoscopy Images of Melanoma


Challenges and limitations of Dermoscopy
Melanoma in its early stages may manifest only as very small changes in skin color, and these changes may be difficult to accurately capture in situ dermoscopy. Some specific types of melanoma, such as limbal freckle-like melanoma or malignant freckle-like nevus-type melanoma may resemble benign lesions, leading to misdiagnosis. Moreover, the diagnostic accuracy of dermoscopy is highly dependent on the experience and skill level of the examiner, and inexperienced physicians may have difficulty accurately recognizing the dermoscopic features of melanoma.


Integration of Dermoscopy with Other Diagnostic Methods
Dermoscopy can be used as a complementary tool to clinical assessment, helping doctors to more accurately observe features such as the shape, color, luster and distribution of skin lesions. When dermoscopy reveals suspected malignant lesions or when the nature of the lesion cannot be determined, it can be combined with skin biopsy for further diagnosis.
Situ dermoscopy can be combined with clinical assessment, skin biopsy and other methods to form a multidisciplinary collaborative diagnostic model. This helps to provide a comprehensive understanding of the condition from multiple perspectives, improving diagnostic accuracy and therapeutic efficacy.


The Role of Dermoscopy in the Early Detection of Melanoma
Dermoscopy is an advanced diagnostic tool for skin imaging, which utilizes optical principles to magnify the microscopic structure of the skin surface, enabling physicians to observe the features of melanoma more clearly. Moreover, it is non-invasive, convenient and intuitive without causing any damage to the patient’s wound.
In addition to relying on specialized medical equipment and doctors for diagnosis, raising public awareness of skin health and self-examination is also an important means of preventing skin diseases such as melanoma. Hospitals or related professionals popularize skin health knowledge to the public, including the prevention of skin diseases such as melanoma, through various channels such as the media, the Internet, and community lectures.

Clinical Case Study of Dermoscopy
Patient Situation: The patient was a middle-aged male who presented to the clinic with the finding of a progressively larger black plaque on his back.
Initial Examination: The doctor first performed a visual observation and found that the black plaque on the patient’s back was irregular in shape, with different shades of color and blurred edges, initially suspecting that it might be a melanoma.

Melanoma


Dermoscopy: Under dermoscopy, the doctor observed a complex network of pigmentation within the plaque, as well as multiple blue-white structures and irregularly distributed spheres and dots.
Diagnostic Findings: To confirm the diagnosis, the doctor recommended a skin biopsy. The biopsy resulted in melanoma.

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