What Are the Rare Skin Cancers? – IBOOLO

Shenzhen Iboolo Optics Co.Ltd was established in Shenzhen, Guangdong since 2012. It is mainly specialized in camera lens. IBOOLO has perennially engaged in the field of digital high-tech product development of high-quality professional and technical R&D team, strong technical force, and it has a number of experienced engineers and professional product development designers.

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What Are the Rare Skin Cancers?

Skin cancer is one of the most common types of cancer. The three most familiar types are basal cell carcinoma, squamous cell carcinoma, and malignant melanoma. However, there are also several rare skin cancers that people often overlook. This article will focus on three of them: Merkel cell carcinoma, Acral lentiginous melanoma, and Kaposi’s sarcoma.Can…

Skin cancer is one of the most common types of cancer. The three most familiar types are basal cell carcinoma, squamous cell carcinoma, and malignant melanoma. However, there are also several rare skin cancers that people often overlook. This article will focus on three of them: Merkel cell carcinoma, Acral lentiginous melanoma, and Kaposi’s sarcoma.
Can IBOOLO Dermatoscope be Used to Observe Skin Cancer?
IBOOLO offers several models, such as the DE-3100 and DE-4100, which are specifically designed for detailed skin lesion examination. These dermatoscopes utilize advanced optical technology, including polarization and non-polarization modes, to provide clear and detailed images of the skin’s surface and subsurface structures.
The IBOOLO Dermatoscope can help medical professionals and even individuals at home to monitor changes in moles, freckles, and other skin lesions, which is crucial for early detection of melanoma and other skin cancers. For example, the DE-4100 features a 10X magnification and three adjustable modes that allow users to observe skin lesions more comprehensively. Additionally, the device is portable and easy to use, making it suitable for both clinical settings and home self-examinations.

DE-4100 IBOOLO Dernatoscope


What Is Merkel Cell Carcinoma?
Merkel cell carcinoma is a rare but aggressive type of skin cancer. It usually appears on sun-exposed areas of the body, particularly the face, head, or neck. The exact cause of Merkel cell carcinoma is not fully understood. However, it’s believed to be related to a combination of factors, including UV exposure and the presence of the Merkel cell polyomavirus (MCV). Most Merkel cell tumors show evidence of this virus. Since it’s a common virus and MCC is rare, scientists are not certain about how or why the virus causes MCC in some people. What is clear is that UV exposure and immunosuppression also play a role. The tumors typically present as firm, painless lesions or nodules. They can be skin-colored, red, purple, or bluish-red. One of the distinctive features of Merkel cell carcinoma is its rapid growth, which often draws the attention of patients and doctors. Early detection is crucial as this cancer can spread quickly to other parts of the body.

Merkel Cell Carcinoma


What Are the Dermatoscopic Features of Merkel Cell Carcinoma?
The dermatoscopic features of Merkel cell carcinoma can vary. However, some common characteristics include a homogeneous red or pink background with irregularly distributed white areas. Telangiectasia (tiny blood vessels) may also be observed. The lesion often appears asymmetrical with irregular borders. Due to the rapid growth of Merkel cell carcinoma, these features can change quickly over time. Dermatoscopy can help in the early identification of such lesions, aiding in the prompt diagnosis and treatment of this aggressive cancer.

Dermoscopic image of mcc


What Is Acral Lentiginous Melanoma?
Acral lentiginous melanoma is a rare and aggressive subtype of melanoma. Unlike many other types of melanoma that are linked to UV exposure, ALM is more likely caused by genetic factors. It commonly appears on hairless skin, such as the palms of the hands, soles of the feet, and under the nails. The lesions are often characterized by a black or brown color. They can be flat or slightly raised and may spread locally. ALM is the most common type of melanoma in people of color, including individuals of African ancestry. Early diagnosis is vital as this type of melanoma can be more challenging to treat once it has advanced.

Acral Lentiginous Melanoma 3


What Are the Dermatoscopic Features of Acral Lentiginous Melanoma?
The dermatoscopic examination of acral lentiginous melanoma reveals several key features. These include asymmetric pigmentation with irregular brown or black streaks, especially under the nails. There may be areas of depigmentation (loss of color) within the lesion. The pigment network is often irregular, and milia-like cysts (small, white bumps) may be present. The borders of the lesion are typically irregular and blurred. These features help dermatologists differentiate ALM from other benign skin conditions that may appear similar.

Acral Lentiginous Melanoma dermatoscope


What Is Kaposi’s Sarcoma?
Kaposi’s sarcoma is a rare skin cancer that originates from the cells lining the blood vessels or lymph vessels. It is caused by the Kaposi’s sarcoma-associated herpesvirus 8 (KSHV). The disease can manifest as red, purple, or brown lesions on the skin, mucous membranes, lymph nodes, and other organs. The lesions may be flat or slightly raised and can grow and spread rapidly. Kaposi’s sarcoma is more common in individuals with weakened immune systems, such as those with HIV/AIDS, organ transplant recipients, and cancer patients receiving chemotherapy.

Kaposi's Sarcoma


What Are the Dermatoscopic Features of Kaposi’s Sarcoma?
The dermatoscopic features of Kaposi’s sarcoma include purplish-red to brownish-red patches or plaques. The lesions often have a mottled appearance with areas of lighter and darker pigmentation. Telangiectasia may be visible within the lesion. The surface may appear smooth or slightly scaly. The borders can be irregular and sometimes indistinct. These characteristics help in distinguishing Kaposi’s sarcoma from other vascular lesions and skin conditions.

kaposi's sarcoma dermatoscope2

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How can dermoscopy images be captured?

Dermoscopy images can be captured and stored in different ways, such as: • Using a smartphone or tablet with dermoscopic adapter, which consisted in the package.• Using a digital camera

Dermoscopy images can be captured and stored in different ways, such as:

• Using a smartphone or tablet with dermoscopic adapter, which consisted in the package.
• Using a digital camera with dermoscopic adapter, there’s 49mm screw size camera adapter available to order now.

Compatible phone/tablet models:
All iPhone models, 95% Android phones, 90% tablet. For phone/tablet size in 5.25-14mm

Compatible camera models:
All camera with built 49mm filter screw, such as Canon EOS 70D, 80D, 90D; Canon EOS R7, R10, R50, R100; Canon M100, M200, M50, Mark II; Canon G7X Mark III, Sony ZV-1

How can I connect my phone to my dermatoscope?

There’s universal phone adapter for all our dermoscopes. Please check the installation procedure bellow or watch operation guide. Smartphone Connector (1) Place phone adapter screw in the center of smartphone’s

There’s universal phone adapter for all our dermoscopes. Please check the installation procedure bellow or watch operation guide.

Smartphone Connector

(1) Place phone adapter screw in the center of smartphone’s main camera.
(2) Screw magnet attachment on phone adapter.
(3) Put dermoscope’s back ring and magnet attachment together

Take The Best Images

You need to adjust the focus ring after the dermoscpe connected on smartphone to get the best images.

How can I clean my dermoscopy after usage?

Cleaning your dermoscopy after usage is important to prevent cross-contamination and infection. The cleaning method may vary depending on the type and model of your dermoscopy, so you should always

Cleaning your dermoscopy after usage is important to prevent cross-contamination and infection. The cleaning method may vary depending on the type and model of your dermoscopy, so you should always follow the manufacturer’s instructions. However, some general steps are:

• Turn off and disconnect your dermoscopy from any power source or device.

• Wipe off any visible dirt or debris from the dermoscopy with a soft cloth or tissue.

• Disinfect the dermoscopy with an alcohol-based wipe or spray, or a disinfectant solution recommended by the manufacturer. Make sure to cover all surfaces, especially the lens and contact plate.

• Let the dermoscopy air dry completely before storing it in a clean and dry place.

• Do not use abrasive or corrosive cleaners, solvents, or detergents that may damage the dermoscopy.

• Do not immerse the dermoscopy in water or any liquid, unless it is waterproof and designed for immersion.

You should clean your dermoscopy after each use, or at least once a day if you use it frequently. You should also check your dermoscopy regularly for any signs of damage or malfunction, and contact the manufacturer or service provider if needed.

Polarized VS Non-polarized Dermoscopy

A dermoscopy is a device that allows the examination of skin lesions with magnificationand illumination. By revealing subsurface structures and patterns that are not visible tothe naked eye. It can

A dermoscopy is a device that allows the examination of skin lesions with magnificationand illumination. By revealing subsurface structures and patterns that are not visible tothe naked eye. It can improve the diagnose accuracy of skin lesions, such as melanoma,basal cell carcinoma, seborrheic keratosis, etc.

There are two main types of dermoscopy: Non polarized and polarized dermoscopy.We’ve fitted most of our dermoscopys with polarized and non-polarized light. They canbe used in multiple skin structures.

Non-polarized contact Mode

In non-polarized mode, the instrument can provide information about the superficialskin structures, such as milia-like cysts, comedo-like openings, and pigment in theepidemis.

The dermoscopy requires applying a liquid such as mineral oil or alcohol to the skin andplacing the lens in contact with the skin. This reduces surface reflection and enhancesthe view of subsurface structures.

Image with non-polarized light (DE-3100)

Polarized contact Mode

In polarized mode, the instrument allows for visualization for deeper skin structures,such as blood vessels, collagen, and pigment in the dermis.

The dermoscopy does not need to be in contact with the skin or use any liquid. Theirpolarized light can help to eliminate surface reflection and allow visualization ofvascular structures.

Image with polarized light (DE-3100)

Polarized non-contact Mode

The dermoscopy can also use polarized light to examine the skin without direct contact.

In polarized non-contact mode, the instrument allows for examination infected areasand lesions that are painful for the patient, or the difficult to contact pigmented lesions,such as nails and narrow areas.

The contact plate should be removed in this mode, and it does not require applying aliquid to the skin. As it doesn’t require pressure or fluid application on the skin, it canalso avoid cross-contamination and infection risk.

Image in polarized non-contact mode (DE-3100)

How effectiveness is dermoscopy

Compared with visual inspection, the dermoscopy can be used to capture and store skin lesion photos, which play an important role in early skin cancer examination. The dermoscopy allows the

Compared with visual inspection, the dermoscopy can be used to capture and store skin lesion photos, which play an important role in early skin cancer examination.

The dermoscopy allows the examination of skin lesions with magnification and illumination. This can be greatly avoiding the factors that cause interference to visual detection. Such as lighting, skin color, hair and cosmetics.

Several studies have demonstrated that dermoscopy is useful in the identification of melanoma, when used by a trained professional.

It may improve the accuracy of clinical diagnosis by up to 35%
It may reduce the number of harmless lesions that are removed
In primary care, it may increase the referral of more worrisome lesions and reduce the referral of more trivial ones

A 2018 Cochrane meta-analysis published the accuracy of dermoscopy in the detection.

Table 1. Accuracy of dermoscopy in the detection of melanoma in adults
Detection Method Sensitivity, % Specificity, % Positive Likelihood Ratio NegativeLikelihood Ratio
Visual inspection alone (in person) 76 75 3.04 0.32
Dermoscopy with visual inspection (in person) 92 95 18 0.08
Image-based visual inspection alone (not in person) 47 42 0.81 1.3
Dermoscopy with image-based visual inspection (not in person) 81 82 4.5 0.23
ROC—receiver operating characteristic. *Estimated sensitivity calculated on the summary ROC curve at a fixed specificity of 80%.

As we can see, the dermoscope can improve the accuracy of diagnosis of skin lesions, especially melanoma.

Table 1. Accuracy of dermoscopy in the detection of melanoma in adults
Detection Method Sensitivity, % Specificity, % Positive Likelihood Ratio NegativeLikelihood Ratio
Visual inspection alone (in person) 79 77 3.4 0.27
Dermoscopy with visual inspection (in person) 93 99 93 0.07
Image-based visual inspection alone (not in person) 85 87 6.5 0.17
Dermoscopy with image-based visual inspection (not in person) 93 96 23 0.07
ROC—receiver operating characteristic. *Estimated sensitivity calculated on the summary ROC curve at a fixed specificity of 80%.

Characteristics of the dermatoscopic structure of the skin lesions include:

• Symmetry or asymmetry
• Homogeny/uniformity (sameness) or heterogeny (structural differences across the lesion)
• Distribution of pigment: brown lines, dots, clods and structureless areas
• Skin surface keratin: small white cysts, crypts, fissures
• Vascular morphology and pattern: regular or irregular
• Border of the lesion: fading, sharply cut off or radial streaks
• Presence of ulceration

There are specific dermoscopic patterns that aid in the diagnosis of the following pigmented skin lesions:

• Melanoma
• Moles (benign melanocytic naevus)
• Freckles (lentigos)
• Atypical naevi
• Blue naevi
• Seborrhoeic keratosis
• Pigmented basal cell carcinoma
• Haemangioma

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